The impact of 10-valent pneumococcal conjugate vaccine on the incidence of admissions to hospital with hypoxaemic and non-hypoxaemic pneumonia in Kenyan children.

ABSTRACT: Observational evidence suggests that pneumococcal conjugate vaccines (PCVs) are more effective at reducing the incidence of hypoxaemic pneumonia compared to non-hypoxaemic pneumonia. We examined the impact of 10-valent PCV (PCV10, Synflorix) on hypoxaemic pneumonia hospital admissions using data from an existing PCV impact study of clinical and radiographic pneumonia. PCV10 was introduced, with catch-up among children under 5 years, in the Kilifi Health and Demographic Surveillance System (KHDSS) in January 2011. We undertook an interrupted time-series (ITS) analysis using seasonally-adjusted segmented Poisson regression of hypoxaemic and non-hypoxaemic pneumonia, accounting for secular trends, from January 2007 to December 2019 among KHDSS residents aged 2-59 months. The median monthly cr

SUBMITTER: Haeusler IL 

PROVIDER: S-EPMC12303342 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature