E-cadherin endocytosis promotes non-canonical EGFR:STAT signalling to induce cell death and inhibit heterochromatinisation.

ABSTRACT: Signalling molecules often contribute to several downstream pathways that produce distinct transcriptional outputs and cellular phenotypes. One of the major unanswered questions in cell biology is how multiple activities of signalling molecules are coordinated in space and time in vivo. Here, we focus on the Signal Transducer and Activator of Transcription (STAT) protein as a paradigm of signalling molecules involved in several independent signalling pathways. Using Drosophila wing discs as an in vivo model, we demonstrate an interplay of at least three STAT activities in this tissue. In addition to the 'canonical' pathways, in which STAT is phosphorylated and activated by Janus Kinases, STAT is involved in two 'non-canonical' pathways. In one pathway, STAT is activated by the Epidermal Gr

SUBMITTER: Ramirez Moreno M 

PROVIDER: S-EPMC12303393 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature