Time of Day-Dependent Responses to Cisplatin Treatment in a Male Mouse Model of Hepatoma.

ABSTRACT: The circadian clock maintains oscillations in gene expression with a 24-hour periodicity in nearly every cell of the body and confers rhythmic patterns to many aspects of behavior and physiology. The presence of circadian rhythms in tumors leads to the question of whether tumors may respond differently to chemotherapy given at different times of day. We addressed this question using a male mouse model of hepatoma by treating mice in the morning (ZT2) or evening (ZT14) with cisplatin, and measuring gross effects on body weight, blood counts and chemistry, gene expression, and cellular proliferation. We found that among cisplatin-treated mice, there was a reduction in expression of the proliferation marker protein Ki-67 in tumors of mice treated at ZT14 as compared to ZT2. Corresponding hepa

SUBMITTER: Akyel YK 

PROVIDER: S-EPMC12303536 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature