Naproxen in High-Temperature Neoplastic Fever: A Case Report Highlighting Its Distinctive Profile among Nonsteroidal Anti-Inflammatory Drugs.

ABSTRACT:

Introduction

Neoplastic fever (NF) is a relatively common yet frequently underrecognized complication in patients with advanced malignancies. NF is characterized by persistent low-grade fever (typically <38.5°C) driven by tumor-associated cytokine release rather than by infectious or autoimmune causes. As a leading contributor to fever of unknown origin in oncology patients, NF is often difficult to diagnose because of its nonspecific clinical presentation and reliance on exclusion criteria. This case illustrates the diagnostic complexity of NF and highlights the clinical value of targeted antipyretic strategies to support timely oncologic decision-making.

Case presentation

A 41-year-old male with stage IVC sigmoid colon adenocarcinoma presented with recurrent high-grade fev

SUBMITTER: Li R 

PROVIDER: S-EPMC12303560 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature