Optimal information gain at the onset of habituation to repeated stimuli.

ABSTRACT: Biological and living systems process information across spatiotemporal scales, exhibiting the hallmark ability to constantly modulate their behavior to ever-changing and complex environments. In the presence of repeated stimuli, a distinctive response is the progressive reduction of the activity at both sensory and molecular levels, known as habituation. In this work, we solve a minimal microscopic model devoid of biological details, where habituation to an external signal is driven by negative feedback provided by a slow storage mechanism. We show that our model recapitulates the main features of habituation, such as spontaneous recovery, potentiation, subliminal accumulation, and input sensitivity. Crucially, our approach enables a complete characterization of the stochastic dynamics, a

SUBMITTER: Nicoletti G 

PROVIDER: S-EPMC12303571 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature