Guideline-based physical activity and health-related quality of life among prostate cancer survivors: a target trial emulation in the Health Professionals Follow-up Study.

ABSTRACT: Prostate cancer and its treatment can impact health-related quality of life. Evidence for physical activity strategies sustained over long periods to improve quality of life is limited. Given the limited feasibility of a randomized trial to answer this question, we emulated a target trial of physical activity strategies based on current clinical guidelines and 6-year quality of life using observational data from 1,549 men in the Health Professionals Follow-up Study diagnosed with nonmetastatic prostate cancer between 2004-2016. Eligible individuals were free of conditions that may preclude high levels of physical activity at baseline. We estimated 6-year mean physical quality of life scores (based on EPIC-CP symptom domains; range: 1-12, lower is better) under sustained, dynamic physical a

SUBMITTER: Chen N 

PROVIDER: S-EPMC12303623 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature