Dexmedetomidine in Mechanically Ventilated Critically Ill Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Purpose

Children undergoing mechanical ventilation (MV) in the pediatric intensive care unit (PICU) require effective sedation to reduce anxiety and discomfort. Dexmedetomidine, an α2-receptor agonist, presents as a viable sedative alternative. However, its clinical outcomes for critically ill, mechanically ventilated children remain to be fully established. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the clinical outcomes and adverse effects of dexmedetomidine in such patients.

Materials and methods

A systematic search was conducted up to April 2024. RCTs that compare dexmedetomidine with other sedatives in mechanically ventilated children were included. This analysis focused on both the clinical and safety outcomes th

SUBMITTER: Lee IK 

PROVIDER: S-EPMC12303668 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature