ATG16L1 promotes cell migration and invasion in high glucose-induced retinal capillary endothelial cells.

ABSTRACT:

Purpose

Diabetic retinopathy (DR), a common chronic complication of diabetes, often results in irreversible visual dysfunction. This study investigated the mechanisms underlying the expression of ATG16L1, a potential biomarker of DR.

Methods

We investigated the role of ATG16L1 in high glucose (HG)-induced retinal capillary endothelial cells (RCECs). Rat RCECs were cultured in normal glucose (NG) or HG medium with or without ATG16L1 transfection.

Results

The mRNA and protein expression levels of ATG16L1 were significantly upregulated in RCECs exposed to HG medium. The migration ability and invasion rate of RCECs were significantly higher in the HG group than in the NG group but decreased markedly after transfection with ATG16L1 siRNA, compared with those in the control

SUBMITTER: Gao X 

PROVIDER: S-EPMC12303877 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature