Angiographic perfusion outperforms large artery vasospasm for predicting the impact of rescue therapy in subarachnoid hemorrhage.

ABSTRACT: Aneurysmal subarachnoid hemorrhage (aSAH) contributes disproportionately to stroke-related disability due to its prevalence in younger patients. Large vessel vasospasm complicates aSAH and is often treated with endovascular rescue therapy (ERT). However, clinical trials have not demonstrated a clear link between vasospasm improvement and better outcomes. We hypothesized that improving vessel caliber alone may not ensure better blood flow to brain parenchyma, and we studied how vessel caliber relates to perfusion in the context of ERT. We measured the internal carotid artery (ICA) caliber and time to maximum of the residual function (Tmax) from digital subtraction angiography (DSA) before and after ERT in 150 vessels from 36 patients. ERT increased ICA caliber (Δ1.13 ± 3.8 mm², p

SUBMITTER: Lyman KA 

PROVIDER: S-EPMC12303933 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature