Lactylation prognostic signature identifies DHCR7 as a modulator of chemoresistance and immunotherapy efficacy in bladder cancer.

ABSTRACT:

Background

Bladder cancer (BLCA), the 10th most common cancer worldwide, presents a worsening prognosis as the disease progresses. Reliable tools for predicting BLCA prognosis and treatment efficacy remain urgently needed.

Methods

Expression profiles of lactylation related genes were analyzed utilizing the Cancer Genome Atlas (TCGA) database and BLCA data from the GSE13507 dataset. Two distinct clusters were identified through unsupervised clustering analysis. Lactylation associated gene signatures were established and subsequently validated using training cohort and different validation cohorts. Immune cell infiltration patterns and drug response profiles were systematically evaluated. Parallel analyses of lactylation related genes were conducted at the single-cell resoluti

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12303948 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature