Prokineticin 2 neurons form diverse subpopulations in the suprachiasmatic nucleus and rely on VPAC2-signaling for diurnal rhythmicity.

ABSTRACT:

Introduction

Prokineticin 2 (PK2) is believed to function as an output molecule, relaying circadian rhythms of behavior and physiology from the suprachiasmatic nucleus (SCN). The expression of PK2 in the SCN is primarily driven by the molecular clock, oscillating with high levels early-mid day and low levels during night. Furthermore, light at night induces the expression of PK2. Until recently, the absence of a reliable PK2 antibody has hindered characterization of PK2 neurons in the SCN, including whether they constitute a phenotypically homogeneous population or comprise distinct subtypes, some potentially light-responsive. Hence, the aim of this study was to characterize PK2 neurons in relations to light-responsiveness and neuropeptidergic markers of the core-shell division.

SUBMITTER: Stangerup I 

PROVIDER: S-EPMC12303973 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature