CD248 induces PD-L1 expression on cancer-associated fibroblasts to promote NSCLC immune escape.

ABSTRACT:

Background

Tumor immune escape is a critical step in tumor progression. Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) express abundant PD-L1 and suppress the functions of CD8⁺T cells, enablingd immune escape. CD248 is a candidate bioindicator for CAFs associated with non-small cell lung cancer (NSCLC), although its involvement in immune escape is not known.

Methods

Fibroblasts were isolated from tumor and normal lung tissues from patients. We detected the expression of CD248 and PD-L1 on CAFs. Then, the influence of CAFs inhibited the function of CD8⁺T cells promoting NSCLC immune escape was assessed in vivo and in vitro. Finally, explored the mechanisms of which CD248 induced PD-L1 expression on CAFs.

Results

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12304000 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature