The Role of Adipokines and Gene Polymorphisms in the Development of Obesity- Induced Depression.

ABSTRACT:

Purpose of review

This review examines the role of adipokines and gene polymorphisms in the development of depression and obesity. It is of great importance to understand the mechanisms that may be effective in the development of obesity and depression as their incidence increases.

Recent findings

Adipokines are released from adipose tissues and primarily regulate the connection between the metabolic and inflammatory effects of obesity and the brain cells and adipose tissue. Adipokines may potentially contribute to the pathophysiology of depression by influencing the HPA axis and neurotransmitters. According to some estimates, the genetic overlap between obesity and depression is as high as 12 percent. Furthermore, these genes may be linked to significant interconnected sign

SUBMITTER: Ercan SN 

PROVIDER: S-EPMC12304030 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature