Relative change rate of liver stiffness measurements predicts the risk of liver decompensation in compensated advanced chronic liver disease.

ABSTRACT: Patients with compensated advanced chronic liver disease (cACLD) have a significant risk of decompensation. Therefore, this study aimed to evaluate the predictive value of dynamic liver stiffness measurements (LSM) for decompensation risk, and their performance across different clinically significant portal hypertension (CSPH) risk stratification. This retrospective cohort study included 1409 patients with cACLD. Patients were divided into no CSPH, probable CSPH, and certain CSPH groups. Competing risk regression analysis was used to identify the independent predictors. The receiver operating characteristic curve and time-dependent area under the curve were used to evaluate the predictive performance. During follow-up, liver decompensation incidence increased with CSPH severity (22.2% with

SUBMITTER: Li Y 

PROVIDER: S-EPMC12304040 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature