Systemic immune-inflammation index and postoperative sleep disturbance in elderly patients with total joint arthroplasty: A prospective cohort study.

ABSTRACT: The systemic immune-inflammation index (SII) has been implicated in various pathological conditions; however, its role in postoperative sleep disturbance (PSD) remains unclear. This prospective cohort study aimed to investigate the association between SII and PSD in elderly patients undergoing total joint arthroplasty. A total of 500 patients (median age: 70 years, IQR: 67-75) were enrolled between August 2023 and October 2024. The optimal SII cut-off value was determined as 500.3 using receiver operating characteristic curve analysis. Patients with SII ≥ 500.3 exhibited a significantly increased risk of PSD, with an odds ratio (OR) of 3.26 (95%CI: 2.23-4.75) in univariate analysis. The association remained robust in three multivariate regression models, with adjusted ORs of 2.14 (95%CI: 1

SUBMITTER: Guo H 

PROVIDER: S-EPMC12304174 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature