Molecular characterization of human respiratory syncytial virus in Mexico (season 2023-2024) through whole-genome sequencing.

ABSTRACT: Human respiratory syncytial virus (hRSV) is a one of major cause of severe acute respiratory infection (SARI) in young children and the elderly. Because genomic surveillance of hRSV is essential to understand viral evolution and the genetic variation that may affect transmissibility and pathogenicity, we sequenced complete genomes of hRSV-A and B from season 2023-2024, isolated from pediatric and adult patients with SARI. One hundred pediatrics and 43 hospitalized adult and 14 non-hospitalized adult patients testing positive for hRSV were enrolled. Libraries of whole hRSV genomes were generated and sequenced on a MiSeq platform. Phylogenetic analysis and maximum likelihood trees were constructed with the 64 hRSV-A and 29 hRSV-B sequences obtained in our study. Additionally, we analyzed the

SUBMITTER: Rivera-Toledo E 

PROVIDER: S-EPMC12304177 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature