Effects of proximal tubule-specific ATRAP enhancement on hypertension in a remnant kidney chronic kidney disease model of mice.

ABSTRACT: Chronic kidney disease (CKD) frequently accompanies hypertension, exacerbating CKD progression in a vicious cycle. Angiotensin II type 1 receptor-associated protein (ATRAP) promotes AT1 receptor internalization to inhibit hyperactivation of its downstream signaling. We previously reported that the downregulation of renal ATRAP expression had a critical role in the development of hypertension in a remnant kidney CKD model, through activation of epithelial sodium channel (ENaC) pathway. Although the distal-tubule was highlighted in CKD-related hypertension, the proximal tubule's role remained unclear. We generated proximal tubule-specific ATRAP transgenic (PT-ATRAP Tg) mice under the control of the Npt2 promoter and compared the effects of 5/6 nephrectomy (Nx) on blood pressure (BP) with tho

SUBMITTER: Okami N 

PROVIDER: S-EPMC12304191 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature