Multi-target drug discovery for rheumatoid arthritis: a comprehensive computational approach using bioactive compounds.

ABSTRACT: Rheumatoid arthritis (RA) is one of the most common inflammatory diseases in the world. Due to this importance, several drugs have been produced against effective targets in the pathogenesis of the disease. Considering various inflammatory pathways involved in RA, targeting each of these pathways alone cannot achieve sufficient improvement of the patients. Therefore, this study aimed to introduce safe natural product drug candidates screened in silico against several important protein targets (multi-targets) in the pathogenesis of RA. Tyrosine kinase 2 is a member of the Janus Kinase family, and due to its role in the signaling of numerous cytokines, its inhibition is considered an effective treatment option in inflammatory diseases. IL-6 is one of the most important innate immune cytokine

SUBMITTER: Mansouri P 

PROVIDER: S-EPMC12304279 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature