Oxidative stress, apoptosis and proliferation in uterus of piglets fed by sow or formula after ex vivo endocrine compound exposure.

ABSTRACT: Endocrine-active compounds (EACs) derived from anthropogenic activities and bioactive components in maternal milk influence neonatal development, a critical period for postnatal uterine morphogenesis. Here, using an ex vivo model, we investigated whether neonatal exposure to the antiandrogen 2-hydroxyflutamide, the environmental estrogen 4-tert-octylphenol, and the organochlorine insecticide metabolite HPTE (which exhibits estrogenic, antiestrogenic, and/or antiandrogenic activity) induces oxidative stress and alters proliferation and apoptosis in uterine explants from 10-day-old piglets. Additionally, we assessed whether natural feeding provides protection against the adverse effects of EACs. We found that EACs disrupting androgen or estrogen signaling increased ROS/RNS production, enhanc

SUBMITTER: Wojtaszek M 

PROVIDER: S-EPMC12304335 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature