Metabolomic Understanding of variable risk factors for kidney cancer: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Circulating metabolites have been found to play an important role in the development of renal cancer, however, the specific pathways and mechanisms of their influence are still largely unknown. We aimed to investigate the role of metabolites in kidney cancer development and to explain the development of kidney cancer from a genetic perspective.

Method

We explored the role of plasma metabolites and urinary metabolites in kidney cancer using two-sample mendelian randomization (MR) separately and validated it using multiple databases; in addition, we performed rigorous tests of pleiotropy and heterogeneity to ensure that the results were robust. Next, we explored the role of common modifiable risk factors in kidney cancer and identified the specific mechanisms by whi

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12304409 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature