Cortical Hemodynamic Abnormalities Associated With Fine Motor Deficits in Mild Cognitive Impairment.

ABSTRACT:

Background

Individuals with mild cognitive impairment (MCI) often exhibit progressive deficits in bimanual coordination and fine motor dexterity. However, the neural mechanisms underlying these motor impairments remain poorly understood.

Aim

This cross-sectional study employed functional near-infrared spectroscopy (fNIRS) to examine cortical hemodynamic responses during fine motor tasks in MCI.

Methods

Thirty individuals with MCI and 40 age-, sex-, and education-matched healthy controls (HCs) performed the Nine-Hole Peg Test (NHPT) while fNIRS monitored oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) responses in the prefrontal cortex (PFC), sensorimotor cortex (SMC), and visual cortex (VC).

Results

Compared to HCs, individuals with MCI exhibited

SUBMITTER: Yang H 

PROVIDER: S-EPMC12304437 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature