Impact of temporal tear meniscus height on the tear osmolarity measurements.

ABSTRACT: Tear hyperosmolarity plays a crucial role in initiation of inflammatory response and damage to ocular surface epithelia. Accurate measurement of tear osmolarity is essential for dry eye. This prospective observational and experimental study was conducted in 182 eyes of 182 participants, including 115 subjects with dry eye (Sjögren syndrome aqueous-deficient dry eye [SS ADDE], non-SS ADDE, and evaporative DE [EDE]), 36 with conjunctivochalasis (CCh), and 31 normal controls (NC). The ocular surface disease index (OSDI), tear meniscus height (TMH), Schirmer I test, tear matrix metalloproteinase-9 (MMP-9), tear breakup time, and ocular staining score were assessed. Tear osmolarity was measured using the TearLab osmolarity system (Escondido, CA, USA) by applying 1.0 μl tears collected by microp

SUBMITTER: Lee J 

PROVIDER: S-EPMC12304470 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature