Salivary Biomarkers of Inflammation in Patients With Chronic Non-Specific Low Back Pain.

ABSTRACT:

Background

Chronic non-specific low back pain (CNSLBP) is a debilitating condition with unclear underlying mechanisms. The presence of systemic biomarkers associated with inflammation in nonspecific low back pain (NSLBP) has been inconsistently reported primarily through invasive blood sampling.

Objective

This study evaluates the use of saliva as an alternative medium for assessing inflammatory biomarker levels in patients with CNSLBP.

Design

Prospective cross-sectional pilot study.

Methods

Twenty-five patients with CNSLBP and 25 age and sex matched asymptomatic participants were selected according to specific inclusion and exclusion criteria. The primary outcome was determination of the levels of inflammatory biomarkers in unstimulated saliva samples of CNSLBP

SUBMITTER: Injeyan HS 

PROVIDER: S-EPMC12304614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature