Longitudinal Changes in Corneal Thickness over 8 Years: Findings from the National Institute for Longevity Sciences-Longitudinal Study of Aging Population-Based Cohort Study in Japan.

ABSTRACT:

Purpose

To evaluate age-related changes in central corneal thickness (CCT) and investigate its relationship with other ocular parameters in community-dwelling Japanese adults through an 8-year longitudinal analysis.

Design

A population-based, prospective longitudinal cohort study with baseline measurements from 1997 to 2000 and follow-up from 2006 to 2008.

Subjects

A total of 631 community-dwelling Japanese adults aged 40 to 79 years (mean age: 55.7 ± 9.7 years) were enrolled from the National Institute for Longevity Sciences-Longitudinal Study of Aging. We excluded participants with corneal pathologies, contact lens use, glaucoma medication, or missing endothelial cell density measurements.

Methods

Central corneal thickness was measured using calibrated specul

SUBMITTER: Fukuoka H 

PROVIDER: S-EPMC12304667 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature