Gut <i>Faecalibacterium</i> abundance in patients with plasma cell disorders is associated with survival after autologous HSCT.

ABSTRACT: The gut microbiota (GM) has been linked to the development, progression, and response to therapy in plasma cell neoplasms (PCNs). The primary goal of this study was to investigate the relationship between the composition of the GM before and during autologous hematopoietic stem cell transplant (HSCT) with clinical outcomes of patients with PCNs. We focused on the genus Faecalibacterium, which includes the most abundant anaerobic commensal bacterium in the GM. Fecal samples were collected prospectively before, mid (at 1 week from the start of intervention), and end (at engraftment) of intervention (liberalized vs neutropenic diet) and subjected to 16S ribosomal DNA sequencing. Eighty-three patients were enrolled. Their median age was 64 (range, 31-79) years. Fifty-four patients recei

SUBMITTER: Dean EA 

PROVIDER: S-EPMC12304682 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature