Protective effect of hydroxytyrosol against hyperglycemia-induced phosphatidylserine exposure in human erythrocytes: focus on dysregulation of calcium homeostasis and redox balance.

ABSTRACT: Diabetes is a widespread chronic disease that poses serious health concerns due to its numerous associated complications, including an increased risk of cardiovascular diseases. Under conditions of prolonged hyperglycemia, erythrocytes (RBC) undergo the breakdown of the natural phospholipid asymmetry, triggered by cell surface exposure of phosphatidylserine (PS) associated with increased prothrombotic activity. The aim of the present study was to provide insights into the potential molecular mechanisms underlying, focusing on two phospholipid translocases, ATP-dependent flippase ATP11C and calcium-dependent scramblase PLSCR1. The possible protective effect exerted by the hydroxytyrosol (HT), a powerful phenolic antioxidant present in olive oil, was also tested. Exposure of intact human RBC

SUBMITTER: Notariale R 

PROVIDER: S-EPMC12304697 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature