Immune cell exhaustion and apoptotic markers in major depressive disorder: Effects of in vitro cannabidiol administration.

ABSTRACT:

Background

Immune dysregulation is a component of Major Depressive Disorder (MDD). Cannabidiol (CBD) has immunomodulatory and putative antidepressant effects. The relationship between apoptotic and exhaustion immune markers and the clinical features of MDD and the effects of CBD on these markers are still unknown.

Objectives

To assess pro-apoptotic (CD95) and T cell exhaustion (TIM3) markers on immune cells in patients with MDD, as well as the impact of in vitro CBD administration on these markers.

Methods

We recruited healthy controls and MDD patients and evaluated the immunophenotypes of T/B lymphocytes using flow cytometry in unstimulated and anti-CD3/CD28 stimulated conditions. We evaluated the immune profiles of M1 macrophages, immune-inflammatory response system

SUBMITTER: Rachayon M 

PROVIDER: S-EPMC12304716 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature