Impact of Ablation Targeting Atrial Drivers and Fragmented Potentials on Long-Standing Persistent Atrial Fibrillation: A Retrospective Study.

ABSTRACT:

Background

Long-standing persistent atrial fibrillation (AF) often shows resistance to pulmonary vein isolation (PVI) alone. This study aimed to compare the outcomes of catheter ablation targeting electrophysiological substrates versus conventional PVI in patients with long-standing persistent AF.

Methods

This retrospective study included 105 patients with long-standing persistent AF who underwent initial catheter ablation between June 2021 and June 2023. After propensity score matching (n = 38 each), we compared conventional PVI (conventional group) with additional ablation targeting AF drivers and fragmented potentials (driver and fragmented potentials group). The primary endpoint was AF recurrence lasting > 30 s occurring ≥ 3 months post-ablation.

Results

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SUBMITTER: Gibo Y 

PROVIDER: S-EPMC12304733 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature