Elevated Serum Gamma-Glutamyl Transferase as a Risk Factor for Frailty in Older Men: A Nationwide Population-Based Study.

ABSTRACT:

Background

Oxidative stress is a key driver of accelerated ageing, and gamma-glutamyl transferase (GGT), an essential enzyme involved in the metabolism of glutathione, a major antioxidant, plays a pivotal role in the generation of free radical species. This study aimed to explore the potential utility of circulating GGT as a biomarker of frailty, which reflects biological ageing and overall health status.

Methods

This cross-sectional, population-based study included 2526 community-dwelling adults aged 65 years and older, using data from the Korea National Health and Nutrition Examination Survey. Frailty was assessed using a deficit accumulation frailty index (FI) derived from 36 items encompassing physical, cognitive, psychological, and social domains. Participants were cate

SUBMITTER: Kang MG 

PROVIDER: S-EPMC12304734 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature