The tacrolimus concentration-to-dose ratio is associated with kidney function in heart transplant recipients.

ABSTRACT:

Aim

Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus-related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration-to-dose [C₀/D] ratio), negatively affects kidney function. Here, the association between the C₀/D ratio and kidney function in HT recipients was investigated.

Methods

This was a retrospective study including 209 HT recipients who received an immediate-release tacrolimus formulation. The C₀/D ratio and kidney function (estimated glomerular filtration rate [eGFR]) were assessed at 3, 6, 12, 36 and 60 months post-HT. Patients were categorized as fast, intermediate and slow metabolisers, depending o

SUBMITTER: Schagen MR 

PROVIDER: S-EPMC12304808 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature