General practitioner consultation for postmenopausal bleeding after COVID-19 vaccination-a self-controlled cohort study.

ABSTRACT:

Aims

The incidence of postmenopausal bleeding (PMB) has been increasing over the past years. Little is known about the risk of PMB after COVID-19 vaccination. Our study aimed to investigate this based on routine general practitioner (GP) healthcare data from the Netherlands.

Methods

A retrospective self-controlled cohort study was performed, which included women aged ≥50 years who received at least 1 COVID-19 vaccination in 2021 and were registered in the GP databases of Nivel (the Nivel Primary Care Database, Nivel-PCD) or PHARMO by 1 January 2021. GP consultations for PMB in the exposed period (28 days after each COVID-19 vaccination) were compared with the nonexposed period (all-time outside the exposed period). Incidence rate ratios (IRRs) were calculated using Poisson r

SUBMITTER: Jajou R 

PROVIDER: S-EPMC12304821 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature