Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery.

ABSTRACT:

Objective

Fat taste sensitivity has been implicated in long-term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients.

Methods

Obesity-induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform transcriptomic activity in the bariatric surgery context. Fat taste detection thresholds (three-alternative ascending forced-choice tests) alongside transcriptomic profiling of freshly isolated fungiform papillae were assessed in women with severe obesity before and 6 months after sleeve gastrectomy.

Results

According to evolution of post surgery detection thresholds, lipid-improved and -unimproved subgroups were identified, despite similar

SUBMITTER: Bernard A 

PROVIDER: S-EPMC12304824 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature