Lipid-associated macrophages are more abundant in subcutaneous than visceral adipose tissue in patients with obesity.

ABSTRACT:

Objective

Because white adipose tissue is infiltrated by several immune cells and their signature in individuals with obesity has not been fully characterized, we wanted to study the most abundant population, which is macrophages, a subtype of myeloid cell.

Methods

To address this objective, we performed transcriptomic analysis of subcutaneous adipose tissue (SAT)- and visceral adipose tissue (VAT)-infiltrated CD11b⁺ myeloid cells from individuals with severe obesity.

Results

Our results showed that gene expression in human white adipose tissue-infiltrated CD11b⁺ myeloid cells was depot-dependent. The expression of lipid-associated macrophage biomarkers was higher in SAT- than VAT-infiltrated CD11b⁺ cells (TREM2, CD9, GPNMB, CD68). In

SUBMITTER: Reyes-Farias M 

PROVIDER: S-EPMC12304837 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature