Early meal timing attenuates high polygenic risk of obesity.

ABSTRACT:

Objective

We examined whether meal timing is associated with long-term weight-loss maintenance and whether meal timing interacts with a genome-wide polygenic score (PRS-BMI) on body weight-related outcomes. We then examined the interaction of meal timing with 97 BMI-related single-nucleotide polymorphisms on obesity outcome.

Methods

Participants (N = 1195, mean age 41.07 [SD 12.68] years, female 80.8%, baseline mean BMI 31.32 [SD 5.53] kg/m²) were adults with overweight or obesity from the Obesity, Nutrigenetics, Timing, and Mediterranean (ONTIME) study. We developed a PRS-BMI to assess the genetic risk for obesity and estimated the timing of the midpoint of meal intake. We also calculated the success in long-term weight-loss maintenance after a dietary obesity tr

SUBMITTER: De la Pena-Armada R 

PROVIDER: S-EPMC12304843 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature