Anticoagulation intensity and outcomes among southeast-Asians with moderate-to-severe mitral valve stenosis.

ABSTRACT:

Objective

To determine the optimal anticoagulation intensity of warfarin in a South-East Asian population with moderate-to-severe rheumatic mitral stenosis.

Methods

A multicentre, retrospective study examined patients with rheumatic mitral stenosis who had not undergone valve replacement or repair and required long-term warfarin therapy at two hospitals in Thailand from 2013 to 2018. The main outcomes were thromboembolism and major bleeding. Incidence rate ratios for these events at each level of anticoagulation intensity (international normalized ratio [INR]) were compared.

Results

The study included 933 patients with 3538 patient-years of follow-up, a mean follow-up of 3.8 years and 23 700 INR values. Mean age was 56.1 ± 11.8 years. During follow-up, there were 149

SUBMITTER: Puchsaka P 

PROVIDER: S-EPMC12304852 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature