Effectiveness and safety of rivaroxaban vs warfarin in patients with pulmonary embolism and right ventricular dysfunction: a retrospective cohort study.

ABSTRACT:

Background

Limited data exist comparing the effectiveness and safety of rivaroxaban and warfarin in patients with right ventricular dysfunction (RVD), a common acute pulmonary embolism (PE) complication.

Objectives

To assess the effectiveness and safety of rivaroxaban compared with warfarin among patients with PE and RVD.

Methods

Adult patients newly prescribed rivaroxaban or warfarin during PE-related hospitalization with evidence of RVD were identified from Mass General Brigham's Research Patient Data Registry database (January 2013-May 2023). Outcomes included time-to-first recurrent venous thromboembolism (VTE) and time-to-first major bleeding event. The proportion of international normalized ratio (INR) measurements within therapeutic range (INR: 2-3) while on wa

SUBMITTER: Laliberte F 

PROVIDER: S-EPMC12304921 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature