Diverse and dynamic influences of saccades on visual representations in the mouse superior colliculus.

ABSTRACT: How do sensory systems account for stimuli generated by natural behavior? We addressed this question by examining how an ethologically relevant class of saccades modulates visual representations in the mouse superior colliculus (SC), a key region for sensorimotor integration. Leveraging the conserved natural tendency to make saccades that reset the eye-head angle to a default position via the optokinetic reflex, we developed an efficient and unbiased "white noise" approach to study the modulation of representations of visual stimuli by stochastically timed resetting saccades in large neuronal populations in awake, untrained head-fixed mice. Extracellular Neuropixels recordings revealed that saccades significantly impacted population representations of the visual probes in the SC, with earl

SUBMITTER: Hunt JB 

PROVIDER: S-EPMC12305052 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature