Bismuth sulfide-titania heterostructure used for photothermal amplified sonodynamic therapy against hypoxic tumor.

ABSTRACT: Hypoxia and electron-hole recombination are two obstacles limiting sonodynamic therapeutic efficacy against cancer. Herein, bismuth sulfide (Bi₂S₃)-titania (TiO₂) heterostructure is designed based on the excellent photothermal property of Bi₂S₃, which could improve intratumor oxygen content through increasing blood flow with the help of near infrared light. Bi₂S₃-TiO₂ heterostructure nanoparticles (NPs) present similar photothermal performance to Bi₂S₃ NPs, while Bi₂S₃-TiO₂ NPs show higher reactive oxygen species (ROS) generating ability than Bi₂S₃ NPs under ultrasonic irradiation. In vitro assessments proved that Bi

SUBMITTER: Chen R 

PROVIDER: S-EPMC12305184 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature