Genetic deregulation of REL in germinal center B cells induces generation of a pool of lymphoma precursor cells.

ABSTRACT:

Abstract

In diffuse large B-cell lymphomas (DLBCLs), gains and amplifications of the 2p15-16 region, which always encompass the REL gene, are mostly restricted to the germinal center (GC) B-cell DLBCL subtype (GCB-DLBCL) for which c-Rel is the pivotal Rel/NF-κΒ subunit. Although REL plays a key role in the GC reaction, its contribution to GCB-DLBCLs remains unclear.To understand the role of REL in the very first steps of GCB transformation, that is, when B cells with deregulated REL are competing with other B cells during chronic antigenic stimulation, we have created a dual-color mouse model that allows to induce REL in a limited pool of activation-induced cytidine deaminase (AID)-imprinted B cells after immunization and to differentially stain AID-imprinted B cells that overexpre

SUBMITTER: Prevaud L 

PROVIDER: S-EPMC12305208 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature