Electric field variations across DLPFC targeting methods in TMS therapy for Alzheimer's disease.

ABSTRACT:

Background

The dorsolateral prefrontal cortex (DLPFC) is crucial for cognitive control and a primary target for transcranial magnetic stimulation (TMS) in Alzheimer's disease (AD). However, understanding the distribution of TMS-induced electric field (E-field) across different targeting methods remains limited, as does its relationship to therapeutic outcomes.

Objective

This study assesses differences in TMS-induced E-field using functional versus anatomical targeting methods for DLPFC stimulation.

Methods

Functional and anatomical targets were identified in 30 (11 M/19F) AD patients and 30 (13 M/17F) age-matched healthy controls (HCs) using T1 and fMRI data. E-field characteristics, including magnitude (E_ROI) and normal component (E_⊥), were calc

SUBMITTER: Wu N 

PROVIDER: S-EPMC12305317 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature