Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing.

ABSTRACT: Diabetic wounds are accompanied with hemorrhage, excessive reactive oxygen species accumulation, microbial infection, and poor exudate management. Current dressings are insufficient to modulate the complex pathophysiological microenvironment of infected diabetic wounds. Here, we develop a facile-fabricated hydrogel film with potent antibacterial and antioxidative properties to significantly accelerate infected diabetic wounds healing. The hydrogel film demonstrates potent antibacterial efficacy against methicillin-resistant Staphylococcus aureus and Escherichia coli, efficient scavenging of the extra- and intracellular reactive oxygen species, and enhanced fibroblast migration. In the methicillin-resistant Staphylococcus aureus infected diabetic wounds model, the hydro

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12305319 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature