CYP2D6 Phenotypes and Emergency Department Visits Among Patients Receiving Opioid Treatment.

ABSTRACT:

Importance

Cytochrome P450 2D6 (CYP2D6) bioactivates hydrocodone, tramadol, codeine, and oxycodone to active metabolites that primarily provide analgesic activity. Reduced CYP2D6 activity may be associated with poor pain control.

Objective

To evaluate associations of impaired CYP2D6 activity based on genotype or CYP2D6 inhibitors, alone and together, with analgesic activity of CYP2D6-metabolized opioids among patients with pain.

Design, setting, and participants

This retrospective national, community-based cohort study used electronic health records and genetics data from the All of Us Research Program. Participants included adults prescribed at least 1 CYP2D6-metabolized opioid for more than 7 days between January 1, 2014, and December 31, 2022, with whole-genome seq

SUBMITTER: Nahid NA 

PROVIDER: S-EPMC12305384 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature