Pathogenic mechanism of intestinal microbiota involved in Guillain-Barre syndrome and with <i>Bifidobacterium</i> intervention.

ABSTRACT:

Introduction

Guillain-Barré syndrome (GBS) is an acute immune-mediated polyneuropathy, involving the peripheral nervous system. The pathogenicity of GBS involves Th17/Treg imbalance, which may be affected by intestinal microbiota. From the previous study, treatment with Bifidobacterium infantis (B. infantis) significantly improved the symptoms of experimental autoimmune neuritis (EAN) through reducing the levels of IL-17A. In the present study, we aimed to further investigate the pathogenic mechanisms of intestinal microbiota involved in GBS, with the intervention of Bifidobacterium.

Material and methods

Lewis rats (n = 18) were injected with P2_53-78 peptide and complete Freund's adjuvant to induce the EAN model. The clinical scores, he

SUBMITTER: Nian D 

PROVIDER: S-EPMC12305515 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature