Alpha-2-Macroglobulin and Signature Genes: Predictive Biomarkers for Prognosis and Immunotherapy in Clear Cell Renal Cell Carcinoma.

ABSTRACT: Alpha-2-macroglobulin (A2M) is a broad-spectrum protease inhibitor that plays a role in maintaining coagulation balance and immune regulation. Previous studies have demonstrated a strong association between A2M and various kidney diseases. However, little is known about the role of A2M in clear cell renal cell carcinoma (ccRCC). In this study, through pan-cancer analysis based on data from multiple public databases such as The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx), a unique prognostic relationship between A2M and ccRCC was identified. A2M expression in three common RCCs and the prognosis were detected, which further proved that A2M was closely related to the prognosis of ccRCC, and the diagnostic value of A2M in ccRCC was determined. Additionally, the results fou

SUBMITTER: Li M 

PROVIDER: S-EPMC12305615 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature