Methylation-based immune deconvolution in prostate cancer patients before and after radical prostatectomy.

ABSTRACT:

Purpose

Surgery, an established short-term immunosuppressive event, may spur dissemination of circulating tumor cells and promote the growth of micrometastases. Whether surgical treatment for prostate cancer (i.e., radical prostatectomy) leads to long-term immune changes is unknown.

Methods

We characterized intra-individual changes in circulating immune cell subsets across a six-month period using serial blood samples from prostate cancer patients pre- and post-radical prostatectomy (n = 11), and from a comparison group managed with active surveillance (n = 8). Immune cell subsets for each patient at each time point were deconvoluted using genome-wide methylation data.

Results

There were no statistically significant intra-individual changes in immune cell proportions

SUBMITTER: Hurwitz LM 

PROVIDER: S-EPMC12305629 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature