Prediction of Bioactive Metabolites from American <i>Aconitum</i> Using Network Integrating Cellular Morphological Profiling and Mass Spectrometry Data.

ABSTRACT: Asian and American Aconitum species are phylogenetically close, but only certain Asian species have been well-studied for their medicinal properties. This study aims to discover bioactive compounds in two American Aconitum species based on a systematic networking strategy integrating both mass spectrometry data and biological profiles from a high-throughput phenotypic screening assay, Cell Painting. The chemical profiles of four different plant parts of two American Aconitum species (A. columbianum and A. uncinatum) were obtained by ion mobility mass spectrometry and compared with two Asian (A. carmichaelii and A. fischeri), and one European species (A. napellus). Biological screening, image analysis, and feature extraction were perfo

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12305659 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature