Genome MLST scheme for tracing genetic diversity and multidrug resistance of food animal-derived <i>Clostridium</i> <i>perfringens</i>.

ABSTRACT: Clostridium perfringens is an important food-borne anaerobic bacterium that can cause chronic disease in humans and animals. The complex toxins that it produces can cause diarrhea, necrotizing enteritis, and even death. This study aimed to evaluate the presence of antibiotic resistance genes and determinants of toxin production in various strains of C. perfringens, derived from different geographical locations and animal sources, through whole-genome sequencing (WGS) and bioinformatics analysis. Antimicrobial resistance testing revealed a notable prevalence of resistance among isolates, with 39.5 % being resistant to clindamycin and 32.6 % resistant to tetracycline. Additionally, 29.1 % of the isolates were found to be resistant to at least two classes of commonly used antibi

SUBMITTER: Wu L 

PROVIDER: S-EPMC12305728 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature