Therapeutic anti-cancer vaccines: a systematic review of prospective intervention trials for common hematological malignancies.

ABSTRACT:

Background

This review comprehensively assesses all prospective trials on anti-cancer vaccines for common hematological malignancies by analyzing trial designs, endpoints, and whether these endpoints are met across these trials.

Methods

We included onco prospective clinical trials involving therapeutic anti-cancer vaccines for hematological malignancies published up to May 2025. We excluded retrospective cohort studies, case reports, non-research opinion publications, and studies not related to hematological malignancies. Information sources: Embase, MEDLINE, Web of Science Core Collection, and ClinicalTrials.gov. All the included RCTs were assessed for bias using the Cochrane Handbook for Systematic Review of Interventions, version 6.2 and Cochrane risk-of-bias tool. Result

SUBMITTER: Shah D 

PROVIDER: S-EPMC12305733 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature