Wen-Shen-Tong-Luo-Zhi-Tong Decoction alleviates bone loss in aged mice by suppressing LONP1-mediated macrophage senescence.

ABSTRACT:

Context

Aging leads to senile osteoporosis (SOP), marked by bone loss and increased fracture risk. Macrophages, as active immune cells in bone tissue, play an important role in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) during aging. Wen-Shen-Tong-Luo-Zhi-Tong Decoction (WSTLZTD), a traditional Chinese herbal formula, has been clinically validated for its efficacy in treating SOP. However, the specific mechanisms by which WSTLZTD exerts its anti-SOP effects-particularly through modulating macrophage senescence-remain unclear.

Objective

The study aims to elucidate the role of WSTLZTD in macrophage senescence and SOP.

Materials and methods

Aged mice received low, medium, high-dose WSTLZTD. Bone loss was evaluated via micro-computed tomograp

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC12305870 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature