Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis.

ABSTRACT:

Background

Transthyretin (TTR) is a highly conserved protein with crucial and broadly protective physiologic roles across organ systems and diseases. Evidence shows that TTR contributes to neuroprotection, cognition, glucose regulation, pregnancy, muscle development, and bone mineralization. In several disease states, including diabetes, Alzheimer's disease, Lewy body dementia, cerebrovascular disease, and osteoporosis, higher TTR levels may be protective. Numerous studies have shown that low levels of TTR are associated with increased mortality overall and in relation to cardiovascular disease and several malignancies.

Purpose

There is a growing portfolio of approved and investigational transthyretin amyloidosis (ATTR) treatments that differ in their mechanisms and effects

SUBMITTER: Gertz MA 

PROVIDER: S-EPMC12305880 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature